RF11 | PSAT368 The role of thyroid peroxidase antibodies on the risk of thyroid cancer: a systematic review and meta-analysis of surgical cohort studies.

Abstract Introduction Hashimoto's thyroiditis raises the risk for differentiated thyroid cancer (DTC) in surgical series, but role of peroxidase antibodies (TPO) remains controversial that regard. We designed present study to evaluate effect preoperative TPO titers DTC. Methods A comprehensive search was conducted PubMed, CENTRAL and Scopus databases November 2021 terms "thyroid cancer" "TPO" or "peroxidase antibodies". characterized differential found patients with high (TPO+), as compared those low undetectable (TPO-) regard Data are expressed odds ratio (OR) 95% confidence interval (CI). Results retrieved reviewed 408 records; 21 retrospective cohort studies (2006-2022) from 7 countries n=30,5536 subjects, fulfilled eligibility criteria: 15 East Asia n=25,125 subjects (82.2%) 6 Western world n=5,428 (17.8%)]. These comprised n=17,684 benign disease (57.9%) n=12,869 DTC (42.1%). The reference used TPO+ 23.6±18.8 (Range 5.1-60.0 IU/ml); n=6,307 were (20.6%) n=24,246 TPO- (79.4%). n=2,960 (46.9%) n=9,909 (40.9), OR 1.28, (95%CI 1.21-1.35), p<0.001. titer associated increased both Asian cohorts, [OR 1.36 (1.28-1.45, p<0.001)] alike, 1.15 (1.02-1.31), p=0.025]. That statistically significantly higher cohorts World Conclusions Thyroid an integral part thyroiditis, which is a well factor seem increase well. seems region. Further needed characterize effects immune response, risk. Presentation: Saturday, June 11, 2022 1:00 p.m. - 3:00 p.m., 1:24 1:29